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Comparison of different Antidepressants

Different Antidepressants


MAOIs act by hindering monoamine oxidase, a complex enzyme framework that metabolizes extra serotonin and epinephrine. Monoamine oxidase inhibitors (MAOIs) are a class of antidepressants. They can be divided into two sorts:

  1. Irreversible MAOIs: which incorporate tranylcypromine and phenelzine
  2. Reversible MAOI, (additionally called a reversible inhibitor of monoamine oxidase A [RIMA]): moclobemide. Moclemide is a kind of antidepressant which is utilized for the treatment of depression and other conditions. It is thought to work by altering the amount of the chemicals in the brain such as dopamine, noradrenaline and serotonin. These chemicals are responsible for the controlling of mood and temperament.

MAOIs holds the negativity of inciting potential life-debilitating issues and subsequently can't be utilized as a part of patients with congestive cardiovascular failure or in those with a background marked by liver infection. It can be hazardous for the individuals who are allergic to its ingredients. It ought to be utilized just when other accessible Antidepressant prescriptions fail as treatment alternatives for depression.


TCAs act for the most part by repressing the reuptake of both norepinephrine and serotonin. Despite the fact that the sort of symptoms experienced by the patient because of TCAs or MAOIs is mostly similar, recurrence of these reactions is much less on account of TCAs. In this manner, TCAs appreciate a superior rate of acceptance by the patients. The Food and Drug Administration (FDA) sanctioned these cyclic antidepressants to treat depression:

Some of the Tricyclic antidepressants are as follows:

Amitriptyline, Amoxapine, Doxepin, Maprotiline, Trimipramine (Surmontil), Protriptyline (Vivactil), Nortriptyline (Pamelor), Imipramine (Tofranil), Desipramine (Norpramin), a tetracyclic antidepressant, likewise is FDA affirmed for depression.

Here and there cyclic antidepressants are utilized to treat conditions apart from depression for example, neuropathic or nerve related pain or anxiety disorders.


The SSRIs work by restraining the serotonin reuptake and are viewed as the most famous, successful and safe prescribed drugs. Prozac, a medication of this class, has demonstrated noteworthy achievement in the treatment of depression and prevention of suicide. It displays less potential after effects when compared with TCAs and MAOIs, and is well-endured.

It ought to be noticed that these three therapeutic classes of drugs share the likeness of easing depressive symptoms in a similar timeframe (1 to 4 weeks). The SSRIs, in view of their advantage of security and tolerability, appreciate the stand of first-line operators. The TCAs are considerably less expensive than SSRIs and are favored by patients who are lethargic to different Antidepressants.


The SNRIs better treat a patient of despondency by aiming to keep both serotonin and norepinephrine at the correct level. The medication bupropion (novel Antidepressant) is exceptional in its effectiveness to hinder the reuptake of dopamine, serotonin and norepinephrine.

Serotonin and noradrenaline are neurotransmitters - chemicals that relay signs between the cells in your brain. SNRIs enhance the amount of these two neurotransmitters in your cerebrum, and this is the way they are thought to enhance the symptoms of despondency.

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